2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID
tolfenamic acid
CAS: 13710-19-5
Molecular Formula: C14H12ClNO2
2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID - Names and Identifiers
| Name | tolfenamic acid |
| Synonyms | CLOTAM gea6414 TOLFENAMIC ACID tolfenamic acid LABOTEST-BB LT00772313 2-(3-CHLORO-O-TOLUIDINO)BENZOIC ACID 2 (3-CHLORO-2-METHYLANILINO)BENZOIC ACID N-(3-Chloro-ortho-tolyl) anthranilic acid n-(2-methyl-3-chlorophenyl)anthranilicacid 2-((3-chloro-2-methylphenyl)amino)-benzoicaci 2-[(4-chloro-3-methylphenyl)amino]benzoic acid 2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID 1,2-Distearoyl-sn-glycero-3-phosphocholine, DSPC |
| CAS | 13710-19-5 |
| EINECS | 237-264-3 |
| InChI | InChI=1/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18) |
| InChIKey | YEZNLOUZAIOMLT-UHFFFAOYSA-N |
2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID - Physico-chemical Properties
| Molecular Formula | C14H12ClNO2 |
| Molar Mass | 261.7 |
| Density | 1.2037 (rough estimate) |
| Melting Point | 210-214°C |
| Boling Point | 405.4±40.0 °C(Predicted) |
| Flash Point | 199°C |
| Water Solubility | Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml). |
| Solubility | Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides. |
| Vapor Presure | 2.66E-07mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White to Off-White |
| Merck | 14,9513 |
| pKa | 3.66±0.36(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5270 (estimate) |
| MDL | MFCD00133865 |
| Use | For the synthesis of non-steroidal anti-inflammatory and analgesic drugs |
2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CB2687500 |
| HS Code | 29224919 |
| Hazard Class | 6.1 |
| Packing Group | III |
2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | tromethic acid is a non-steroidal anti-inflammatory drug, which is a kind of antipyretic, analgesic and anti-inflammatory drug widely used in clinic. tromethic acid (Tolfenamicacid), an o-aminobenzoic acid derivative developed by GEA Company of Denmark. |
| characteristics | the anthranilic acid derivative (Tolfenamicacid) developed by Danish GEA company has an IC50 of 15.0 for inhibiting cyclooxygenase COX-1/COX-2, indicating that tromethic acid has strong selectivity to COX-2, so it has strong anti-inflammatory and analgesic effects and less side effects. |
| application | trophate plays an antipyretic and analgesic effect by inhibiting the production of cyclooxygenase. at present, it is mainly used in the treatment of rheumatoid arthritis, migraine and other diseases clinically. in recent years, scholars at home and abroad have conducted various researches on this, it is found that trophate also plays an important role in inhibiting the growth of tumor cells, inducing tumor cell apoptosis, interfering with tumor cell signal transduction, regulating the activity of proto-oncogenes and tumor suppressor genes, and inhibiting tumor angiogenesis. It also plays an important role in bladder adenocarcinoma, esophageal cancer, Colorectal cancer, prostate cancer, lung cancer, breast cancer, ovarian cancer, thyroid cancer, neuroblastoma, rhabdomyosarcoma, head and neck tumors and other tumor cells have shown inhibitory effects, it has shown potential clinical application prospects in the field of anti-tumor. |
| biological activity | Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. |
| Target | Value |
| COX-2 | 0.2 μM |
| use | for synthetic non-steroidal anti-inflammatory analgesics |
Last Update：2024-04-10 22:29:15
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